Neurovascular Coupling Accuracy in fMRI

Dec 12, 2025, TU Munich and FAU Erlangen-Nuremberg found 40% of fMRI signals contradict actual brain activity.
Neurovascular coupling is accurate 60% of the time as regions meet energy needs via oxygen extraction, not blood flow.
Quantitative MRI measured oxygen consumption and BOLD signals in 40 participants during mental tasks, revealing regional variations.
Tens of thousands of fMRI studies on depression and Alzheimer’s require reinterpretation.
AI/ML developers face up to 40% training label errors due to fMRI data inconsistencies.
Researchers recommend combining fMRI with Quantitative MRI and cross-validating with EEG/PET for energy-based brain models.
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