Stem Cell Regeneration Through Lysosomal Correction
Study published in Cell Stem Cell shows lysosomal defects can be corrected.
Lysosomes act as the cell's recycling system for breaking down biomolecules.
Team focused on hematopoietic stem cells generating blood and immune cells.
Aged HSC lysosomes were hyper-acidic and damaged via single-cell transcriptomics.
Vacuolar ATPase inhibitor restored lysosomal integrity, boosting blood-forming capacity eightfold.
Treated stem cells regained youthful function with reduced inflammation.
Research supported by NIH and Imagine Institute in Paris.
Investigating lysosomal defects' role in leukemic stem cell formation.
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