TP53 Mutation in ESB Donor Causes Cancer Risk
Donor 7069 had rare TP53 mutation linked to Li-Fraumeni syndrome.
Routine screening missed TP53 mutation, leading to undetected issue.
ESB blocked in October 2023.
10 children diagnosed with cancer, 23 of 67 affected children carried the variant.
Quarantine of samples followed unevenly.
Denmark notified HFEA, Belgium opened investigations.
Advocacy groups demand Europe-wide caps.
Half-siblings face lifelong screening with annual MRI/ultrasounds.
TP53 mutation links to 90% cancer risk.
1 month ago