Genetic Mutations in Cloned Mice

University of Yamanashi researchers published study in Nature Communications on cloning limits.
20-year experiment produced 1,200 mice over 58 generations.
First 25 generations healthy, later ones had fatal mutations.
Chromosomal abnormalities (X loss) three times higher than natural mating.
58th generation died due to mutations.
Sexual reproduction essential for long-term survival.
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